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acto.owl: AACT information and structure transformed into the knowledge base ACTO (By Hendrik ter Horst) AACT relational database containing information from clinicaltrial.gov (https://aact.ctti-clinicaltrials.org/)

Visualizations:

  1. The T-Box visualization with NamedIndividuals
  2. The T-Box visualization without the NamedIndividuals ( there it is easier to understand the important relations) Both visualizations are in .graphml and can be opened with yed, for example.

Technical information:

The CT-knowledgebase describes 381.677 clinical studies with 219.200.836 triples totalling ~32,1 GB. (14.9.2021) This KB easily fits into memory and runs reasonable fast (with the java jena api). It describes 7.684 clinical studies with 1.822.664 triples.

If you also want to work with this smaller KB: NCT046xxxxx.n-triples.zip https://uni-bielefeld.sciebo.de/s/GftCKwdkd7yzPkr An example query on this smaller knowledgebase:

> PREFIX  acto: <http://acto.de/ontology/>
> SELECT DISTINCT  ?trial_nct_id
> WHERE
>   { ?trial    acto:hasIntervention  ?intervention .
>     ?intervention
>               acto:hasInterventionType  acto:Biological .
>     ?trial    acto:hasPhase         acto:Phase_3 ;
>               acto:hasIdInfo        ?idInfo .
>     ?idInfo   acto:hasNctId         ?trial_nct_id
>   }
>
> returns all NCT-ids of clinical studies that are in phase 3 and have a biological intervention type. 
> The query returns the following 56 ids:
> NCT04648241,NCT04618640,NCT04689165,NCT04676412,NCT04608318,NCT04649515,NCT04644484,NCT04646590,NCT04605159,NCT04632927,NCT04651790,NCT04680962,NCT04633226,NCT04656418,NCT04636268,NCT04687072,NCT04607629,NCT04689191,NCT04641481,NCT04614948,NCT04642079,NCT04695717,NCT04650399,NCT04642339,NCT04636229,NCT04618939,NCT04612465,NCT04617483,NCT04659239,NCT04633564,NCT04691544,NCT04612972,NCT04671433,NCT04640142,NCT04611802,NCT04629833,NCT04628494,NCT04667039,NCT04636853,NCT04697381,NCT04683003,NCT04624204,NCT04628767,NCT04612790,NCT04662710,NCT04673786,NCT04605926,NCT04669015,NCT04635423,NCT04634877,NCT04691908,NCT04679103,NCT04656613,NCT04689152,NCT04674800,NCT04674189

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Clinical trial knowledge base: ACTO

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